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It has been shown that glucagon can bind to GLP-1R, with a 1001000-fold decreased affinity than GLP-1, promoting insulin release due to its homology with GLP-1

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For example, Ozempic is approved to decrease the risk of kidney disease and death from cardiovascular disease in people with Type 2 diabetes

GLP-1 receptor agonists are a class of medications primarily licensed for the treatment of type 2 diabetes mellitus and, in some formulations, for weight management in adults with obesity or overweight with weight-related comorbidities

You have a higher risk of kidney and/or heart disease